Compassionate Guide to Obesity: Appetite, Biology & Support

By Dr Mohgah Elsheikh: Obesity isn’t just a number on a scale—it’s a complex condition shaped by biology, environment, psychology, and behaviour. Let’s explore why it’s time to move beyond myths and embrace understanding and compassion.

 

Why We Need to Change the Conversation

Too often, obesity is oversimplified as “laziness” or “poor self-control,” but the overwhelming majority of people with obesity have tried countless diets, exercise routines and calorie-counting efforts with relentless dedication.

These efforts reflect determination, not a lack of willpower. So why does weight loss prove so elusive? The real story lies in the brain’s appetite systems.

 

The Biology of Appetite: Not a Choice

Hormones and Hunger

Two key hormones—leptin and ghrelin—play starring roles. Leptin signals fullness, while ghrelin triggers hunger. These signals begin deep in the brain, long before we even realise we’re hungry. For many people with obesity, these signals become amplified. They feel hungry more often, feel full less and experience intense cravings beyond conscious control.

 

Genes, Stress & Sleep

Genetics, early-life experiences, chronic stress and disrupted sleep influence appetite regulation. The modern environment—filled with calorie-dense, convenient foods and targeted marketing—only magnifies the challenge.

 

Energy Balance vs. Appetite Dysregulation

The classic “calories in, calories out” model assumes everyone can simply eat less and move more. But if hunger-system “defences” kick in—making you feel ravenous, less satiated, or prone to cravings—that approach usually fails.

People with obesity often exhaust themselves trying to outsmart biology. The result? Repeated cycles of dieting and regain. It’s not about a weak will; it’s about a brain wired to protect your weight.

 

Myths, Met & Debunked

1. “BMI is useless.”

  • While BMI has limitations—since it doesn’t consider muscle mass or fat distribution—it remains a valuable public-health screening tool when used appropriately.

2. “It’s the hormones.”

  • Hormonal changes influence weight, but conditions like thyroid disorders or menopause don’t fully explain obesity. Appetite regulation plays a far more central role.

3. “Obesity is a choice.”

  • Neural circuits controlling hunger function largely outside of conscious awareness. This isn’t an excuse—it’s biology.

 

A More Effective, Compassionate Approach

What if instead of blaming willpower, we acknowledged biological reality? Here’s a more caring, evidence-based framework:

1. Eliminate Stigma

Frame obesity not as moral failure, but as a health condition influenced by many uncontrollable factors.

2. Target Biology

Investigate treatments—such as medications—that help reset appetite signals, reduce hunger and increase feelings of fullness.

3. Educate Everyone

Equip both patients and healthcare providers with a deeper understanding of obesity’s drivers—genes, hormones, environment, psychology—not just calories.

4. Reframe Responsibility

Rather than urging patients to “just try harder,” support them in accessing evidence-based interventions and building sustainable habits.

5. Embrace Whole-Person Care

Consider the broader context: mental health, stress, social factors, sleep, physical activity—not just weight metrics.

 

Why This Matters

  • Improved outcomes: When treatments address appetite and biology, people can lose weight and keep it off more effectively than dieting alone.

  • Reduced health burden: Compassionate care leads to better mental well-being and physical health.

  • Public health impact: A deeper understanding combats prejudice and promotes policies that support healthier environments.

 

Key Takeaways

Myth: Laziness equals Obesity. Truth: Most people with obesity have tried hard to lose weight.

Myth: Weight loss is just diet. Truth: Appetite biology often fights back, resetting hunger and fullness levels.

Myth: Obesity is a personal choice. Truth: Biological and environmental forces largely shape our weight set‑point.

 

Your Role in Compassionate Care

If you are living with obesity:

  • Know it’s not just about “eating less.” Biology plays a big part.

  • Explore treatments that target appetite (like medications, structured intervention programmes or even surgery).

  • Seek healthcare providers who offer non-judgmental, science-based support.

  • Embrace lifelong changes in sleep, stress management, mindfulness and movement.

If you are caring for others living with obesity share this understanding. Offer support, not judgement. Help them access treatments that work with biology, not against it.

 

Final Thoughts

Obesity is a complex, common, chronic condition, not a moral failing or lack of willpower. By recognising the intricate interplay of hormones, brain circuits, stress, sleep, and genetics, we can shift from blame to empathy. The result?

  • Better weight-loss outcomes

  • Less stigma and more acceptance

  • A society better equipped to support health and well-being

Together, let’s reshape the obesity narrative—toward evidence, compassion, and real solutions.

 

Dr. Mohgah Elsheikh is a specialist in Endocrinology, Obesity and Bariatric Medicine, committed to empowering patients through understanding, support and scientific insight.